Pediatric Immunization Advancement
Pannaraj Lab
In the News
In The News:
1. Some moms look to breast milk to protect kids too young to be vaccinated
https://www.wfyi.org/news/articles/moms-breast-milk-banks-kids-vaccinated
2. The Youngest Babies Still Can’t Get Vaccinated Against COVID-19,
But Maternal Vaccination Can Protect Them
3. 2 million California kids are now eligible for COVID vaccine. How many will get it?
https://www.latimes.com/california/story/2022-06-22/california-kids-under-5-eligible-covid-vaccine
4. Millions of Americans Can't Isolate From COVID in The Home.
https://www.cbsnews.com/news/covid-19-isolation-exposure-home/
5. Does weight affect COVID-19 symptoms in individuals with mild forms of COVID-19?
6. Young Teens can Get the COVID Vaccine. Here is what you need to know
https://www.kcrw.com/news/shows/greater-la/vaccine-teens-girardi-vegan/covid-vaccine-teens
7. Effectiveness of Pfizer-BioNTech mRNA Vaccination Against COVID-19 Hospitalization Among Persons Aged 12–18 Years
https://www.cdc.gov/mmwr/volumes/70/wr/mm7042e1.htm
8. Even With Mild COVID, Obesity May Mean Worse Symptoms
9. Clinical manifestations of COVID-19 differ by age and obesity status
https://onlinelibrary.wiley.com/doi/10.1111/irv.12918
10. Saliva Testing After COVID-19 Exposure
https://www.jwatch.org/na53967/2021/08/24/saliva-testing-after-covid-19-exposure
11. CHLA Investigator Receives $3.4 Million Research Grant to Study Rotavirus Vaccine
12. News-Medical - Children's Hospital Los Angeles is U.S. site for new study of SARS-CoV-2 spread within households."
13. "Children’s Hospital Los Angeles Awarded $3 Million to Study How Baby’s First Flu Exposure Affects Later Vaccine Response."
14. "The flu season is hitting young people particularly hard. And it’s not over."
https://www.latimes.com/california/story/2020-01-17/flu-season-young-people-influenza-b
15. "Burden of RSV-related hospitalization continues after discharge for caregivers."
16. "Definitely not an anti-vaxer': Some parents push back against recommended vaccine schedule."
https://www.cnn.com/2019/03/15/health/vaccine-schedule-delay-partner/index.html
17. "Despite California's Strict New Law, Hundreds of Schools Still Don't Have Enough Vaccinated Kids."
https://www.latimes.com/health/la-me-kindergarten-vaccination-20170813-htmlstory.html
18. "Breast-feeding's role in 'seeding' infant microbiome."
https://www.sciencedaily.com/releases/2017/05/170508112411.htm
19. "Flu can be deadly, even in healthy kids."
https://www.cnn.com/2012/10/24/health/flu-fatalities/index.html
20. "School-Based Flu Shots Deliver Benefits."
https://www.youtube.com/watch?v=5QrnPq1ZOss
21. "Flu vaccinations at school clinics cut infection rates, improved attendance."
Selected Recent Publications:
1. Chwa JS, Kim M, Lee Y, Cheng WA, Shin Y, Jumarang J, Bender JM, Pannaraj PS. Detection of SARS-CoV-2 Specific Secretory IgA and Neutralizing Antibodies in Nasal Secretions of Exposed Seronegative Individuals. Viruses 2024;16(6):852. PMID: 38932145
2. Domachowske J, Hamrén UW, Banu I, Baronio R, Basavaraju B, Koen A, Leach A, Mankad VS, Pannaraj PS, Soler-Palacin P, Takas T, Mori M, Villafana T; MUSIC Study Group. Safety and Pharmacokinetics of Nirsevimab in Immunocompromised Children. Pediatrics. 2024 Oct 1;154(4):e2024066508. PMID: 39257380
3. Chwa JS, Shin Y, Lee Y, Fabrizio T, Congrave-Wilson Z, Cheng WA, Jumarang J, Kim M, Webby R, Bender JM, Pannaraj PS. SARS-CoV-2 Variants May Affect Saliva RT-PCR Assay Sensitivity. J Appl Lab Med. 2024 Sep 9. Online ahead of print. PMID: 39246012
4. Parker RS, Le J, Villa M, Luong A, Lin TY, Lee Y, Doan A, Aguayo-Hiraldo P, Pannaraj PS, Yoon SJ, Wallace WD, Armstrong A, O'Gorman MR, Bard JD, Parekh C. COVID-19 vaccinated children, adolescents, and young adults with acute lymphoblastic leukemia show spike reactive antibodies and multifunctional T-cells. Int J Cancer. 2024 Jul 15. Online ahead of print. PMID: 39005114
5. Zambrano LD, Newhams MM, Simeone RM, Payne AB, Wu M, Orzel-Lockwood AO, Halasa NB, Calixte JM, Pannaraj PS, …Campbell AP, Randolph AG. Durability of Original Monovalent mRNA Vaccine Effectiveness Against COVID-19 Omicron–Associated Hospitalization in Children and Adolescents — United States, 2021–2023. MMWR Morb Mortal Wkly Rep 2024;73:330–338. PMID: 38635481
6. Rowan CM, LaBere B, Young CC, …Campbell AP, Randolph AG, Chou J; Overcoming COVID-19 Investigators. Pre-existing Immunocompromising Conditions and Outcomes of Acute COVID-19 Patients Admitted for Pediatric Intensive Care. Clin Infect Dis. 2024 Mar 11 Online ahead of print. PMID: 38465976
7. Kim M, Cheng WA, Congrave-Wilson Z, Ruiz CJM, Turner L, Mendieta S, Jumarang J, Del Valle J, Lee Y, Fabrizio T, Allen EK, Thomas PG, Webby R, Gordon A, Pannaraj PS. Comparisons of Pediatric and Adult SARS-CoV-2-Specific Antibodies up to 6 Months after Infection, Vaccination, or Hybrid Immunity. J Pediatric Infect Dis Soc. 2024 Jan 29;13(1):91-99. PMID: 38016076
8. Zambrano LD, Newhams MM, Simeone RM, Fleming-Dutra KE, Halasa N, Wu M, Orzel-Lockwood AO, Kamidani S, Pannaraj PS, … Campbell AP, Randolph AG; Overcoming COVID-19 Investigators. Characteristics and Clinical Outcomes of Vaccine-Eligible US Children Under-5 Years Hospitalized for Acute COVID-19 in a National Network. Pediatr Infect Dis J. 2024 Mar 1;43(3):242-249. PMID: 38145397
9. Simeone RM, Zambrano LD, Halasa NB, Fleming-Dutra KE, Newhams MM, Wu MJ, Orzel-Lockwood AO, Kamidani S, Pannaraj PS, …Campbell AP, Randolph AG; Overcoming COVID-19 Investigators. Effectiveness of Maternal mRNA COVID-19 Vaccination During Pregnancy Against COVID-19-Associated Hospitalizations in Infants Aged <6 Months During SARS-CoV-2 Omicron Predominance - 20 States, March 9, 2022-May 31, 2023. MMWR Morb Mortal Wkly Rep. 2023 Sep 29;72(39):1057-1064. PMID: 37874864
10. Halasa N, Zambrano LD, Amarin JZ, Stewart LS, Newhams MM, Levy ER, Shein SL, Carroll CL, Fitzgerald JC, Michaels MG, Bline K, Cullimore ML, Loftis L, Montgomery VL, Jeyapalan AS, Pannaraj PS, … Randolph AG, Campbell AP; RSV-PIC Investigators. Infants Admitted to US Intensive Care Units for RSV Infection During the 2022 Seasonal Peak. JAMA Netw Open. 2023 Aug 1;6(8):e2328950. PMID: 37581884
11. Congrave-Wilson Z, Kim M, Sutherland A, Jumarang J, Lee Y, Del Valle J, Cheng WA, da Silva Antunes R, Pannaraj PS. Effect of wash media type during PBMC isolation on downstream characterization of SARS-CoV-2-specificT cells. J Immunol Methods. 2023 Jun 29. 2023 Aug;519:113520. PMID: 37390890
12. Habel JR, Chua BY, Kedzierski L, Selva KJ, Damelang T, Haycroft ER, Nguyen TH, Koay HF, Nicholson S, McQuilten HA, Jia X, Allen LF, Hensen L, Zhang W, van de Sandt CE, Neil JA, Pragastis K, Lau JS, Jumarang J, Allen EK, Amanant F, Krammer F, Wragg KM, Juno JA, Wheatley AK, Tan HX, Pell G, Walker S, Audsley J, Reynaldi A, Thevarajan I, Denholm JT, Subbarao K, Davenport MP, Hogarth PM, Godfrey DI, Cheng AC, Tong SY, Bond K, Williamson DA, McMahon JH, Thomas PG, Pannaraj PS, James F, Holmes NE, Smibert OC, Trubiano JA, Gordon CL, Chung AW, Whitehead CL, Kent SJ, Lappas M, Rowntree LC, Kedzierska K. Immune profiling of SARS-CoV-2 infection during pregnancy reveals NK cell and γδ T cell perturbations. JCI Insight. 2023 Apr 10;8(7):e167157. PMID: 37036008
13. Zambrano LD, Newhams MM, Olson SM, Halasa NB, Price AM, …Pannaraj PS, Cameron MA, Walker TC, Schwartz SP, Michelson KN, Coates BM, Flori HR, Mack EH, Smallcomb L, Gertz SJ, Bhumbra SS, Bradford TT, Levy ER, Kong M, Irby K, Cvijanovich NZ, Zinter MS, Bowens C, Crandall H, Hume JR, Patel MM, Campbell AP, Randolph AG. Risk Factors for Multisystem Inflammatory Syndrome in Children: A Case-Control Investigation. Pediatr Infect Dis J. 2023 Apr 7. Online ahead of print. PMID: 37000922